Reference Range

SSA

<7   = Negative
7-10 = Equivocal
>10  = Positive

SS-A/Ro - Of interest and significance for the clinical diagnosis of SLE (prevalence 40-50%) and Sjogrens syndrome (prevalence 60-75% for primary Sjogrens syndrome). They have been reported to occur in tight association with certain disease subsets, such as subacute cutaneous LE, neonatal lupus erythematosus or vasculitis in Sjogrens syndrome. As anti SS-A/Ro may be the only antibody present in many patients with SLE or Sjogrens syndrome, failure to measure SS-A/Ro leaves a diagnostic void which cannot be filled by other tests.

SSB

<7   = Negative
7-10 = Equivocal
>10  = Positive

SS-B/La - Serological hallmark of Sjogrens syndrome, but a small proportion of patients remain SS-B/La negative. Reported in 6 to 15% of sera from SLE patients, SS-B/La antibodies are associated with a lower prevalence of dsDNA antibodies and renal disease in these patients. Although a strong association of neonatal lupus erythematosus (NLE) with anti SS-A/Ro was recognized first, the majority of mothers with babies with NLE are now known to have serum SS-B/La antibodies as well.

Testing was performed on the Phadia 250 analyzer using Fluorescence Enzyme Immunoassay technology.

*Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current data.